Abstract:

The ubiquitin-proteasome system (UPS) is one of the commonest way to degrade protein in eukaryotic cells. The UPS is responsible for degrading the destroyed and misfolded proteins to regulate different biological processes. Ubiquitin carboxy-terminal hydrolase L1(UCH-L1), as a member of deubiquitinating enzymes (DUB), has both functions of hydrolyzation and conjunction with ubiquitin. In addition to playing an important role in neurodegenerative diseases and tumors, the role of UCH-L1 in the ocular diseases is still worth exploring. UCH-L1 may be related to the development of cataract, optic nerve damage of glaucoma and promotion of ocular neovascular disease. (Int Rev Ophthalmol,  2017,  41:   390-395)